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| Zhonghua Zhong Liu Za Zhi 1992 Jan;14(1):48-50 |
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Inhibitory effect of refined
Amorphophallus konjac on MNNG-induced lung cancers in mice
[Article in Chinese]
Luo DY.
Institute of Cancer Research, West China University of Medical
Sciences, Chengdu.
550 seven-wk-old LACA mice were used in 3 batches for studying
the inhibitory effect of refined Amorphophallus konjac (Konjaku
powder) on MNNG-induced lung cancers. The mice (within each
batch) were randomly allocated into four groups, namely, positive
control (MNNG), Amorphophallus konjac (A. K.), complex (MNNG+A.
K.), and blank control (C) groups. In MNNG group, MNNG (250
micrograms) was injected intravenously once every five days
for seven times in each mouse, the total dosage of MNNG being
1.75 mg. In A. K. group, according to w/w, 8% A. K. was well
mixed into 92% common diet for long-term breeding. In the complex
group, MNNG was given as that in MNNG group and the mice were
kept as those in A. K. group. The mice in MNNG group and in
C group were all maintained on common diet. The results showed
different degrees of inhibitory and preventive effect of refined
A. K. on MNNG-induced lung cancers. Refined A. K. not only exerted
effect on the number of induced cancer and precancerous lesions,
causing a drop in cancer rate from 70.87% to 19.38% and the
mean number of cancer and precancerous lesions in each animal,
but also altered the constituent ratio of the kinds of tumors,
showing a decrease in malignancy (adenoma with malignant change),
absence of adenocarcinoma, and relative increase in benign adenoma.
The results of experiments in 3 batches also exhibited good
reproducibility as well as absence of adverse reaction to Konjaku
powder.
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