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| Hua Xi Yi Ke Da Xue Xue Bao 1992 Mar;23(1):75-8 |
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Antisteatotic effects of
four kinds of dietary fibers in rats fed on high cholesterol
diet: a preliminary morphometric analysis
[Article in Chinese]
Zhang Y, Zheng Z, Zeng X, Tan J, Wu J.
The hypolipidaemic and antisteatotic effects of the Konnyaku
Powder (KP) have been reported before. In order to evaluate
further the antisteatotic role played by KP, the effects of
KP on the levels of liver lipid and on the hepatic histopathology
and morphometry in comparison with those of pectin, algin and
agar were studied. Sixty Wistar strain rats were divided into
6 groups: a normal diet group, a high cholesterol diet group
(HC), and 4 test groups, in which the animals were fed on a
diet similar to that of the high cholesterol diet group with
addition of KP, pectin, algin or agar at a dosage of 5%, respectively.
All the animals were killed at the end of the diet treatment
for 9 weeks. The results showed that relative liver weights
were lower in four experimental groups than in the HC group.
The levels of total and free cholesterol, and triglyceride in
the liver were lower in KP group than in HC group and in the
other three experimental groups. Hepatic histopathology and
morphometric examination indicated that antisteatotic effects
of KP appeared to be much more significant than those of the
other fibers.
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