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| Diabetes Care 2000 Jan;23(1):9-14 |
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- Beneficial effects of
viscous dietary fiber from Konjac-mannan in subjects with the
insulin resistance syndrome: results of a controlled metabolic
trial.
Vuksan V, Sievenpiper JL, Owen R, Swilley JA, Spadafora P,
Jenkins DJ, Vidgen E, Brighenti F, Josse RG, Leiter LA, Xu Z,
Novokmet R.
Department of Nutritional Sciences, St. Michael's Hospital,
University of Toronto, Canada. v.vuksan@utoronto.ca
OBJECTIVE: Dietary fiber has recently received recognition for
reducing the risk of developing diabetes and heart disease.
The implication is that it may have therapeutic benefit in prediabetic
metabolic conditions. To test this hypothesis, we investigated
the effect of supplementing a high-carbohydrate diet with fiber
from Konjac-mannan (KJM) on metabolic control in subjects with
the insulin resistance syndrome. RESEARCH DESIGN AND METHODS:
We screened 278 free-living subjects between the ages of 45
and 65 years from the Canadian-Maltese Diabetes Study. A total
of 11 (age 55+/-4 years, BMI 28+/-1.5 kg/m2) were recruited
who satisfied the inclusion criteria: impaired glucose tolerance,
reduced HDL cholesterol, elevated serum triglycerides, and moderate
hypertension. After an 8-week baseline, they were randomly assigned
to take either KJM fiber-enriched test biscuits (0.5 g of glucomannan
per 100 kcal of dietary intake or 8-13 g/day) or wheat bran
fiber (WB) control biscuits for two 3-week treatment periods
separated by a 2-week washout. The diets were isoenergetic,
metabolically controlled, and conformed to National Cholesterol
Education Program Step 2 guidelines. Serum lipids, glycemic
control, and blood pressure were the outcome measures. RESULTS:
Decreases in serum cholesterol (total, 12.4+/-3.1%, P<0.004;
LDL, 22+/-3.9%, P<0.002; total/HDL ratio, 15.2+/-3.4%, P<0.003;
and LDL/HDL ratio, 22.2+/-4.1%, P< 0.002), apolipoprotein
(apo) B (15.1+/-4.3%, P<0.0004), apo B/A-1 ratio (13.1+/-3.4%,
P< 0.0003), and serum fructosamine (5.2+/-1.4%, P<0.002)
were observed during KJM treatment compared with WB-control.
Fasting blood glucose, insulin, triglycerides, HDL cholesterol,
and body weight remained unchanged. CONCLUSIONS: A diet rich
in high-viscosity KJM improves glycemic control and lipid profile,
suggesting a therapeutic potential in the treatment of the insulin
resistance syndrome.
Publication Types:
- Clinical Trial
- Multicenter Study
- Randomized Controlled Trial
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