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| Endocr J 1995 Apr;42(2):187-92 |
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Long-term effects of dietary
fiber supplementation on serum glucose and lipoprotein levels
in diabetic rats fed a high cholesterol diet.
Hozumi T, Yoshida M, Ishida Y, Mimoto H, Sawa J, Doi K, Kazumi
T.
Department of Medicine, Hyogo Medical Center for Adults, Akashi,
Japan.
We have shown that cholesterol-fed diabetic rats developed atheromatous
lesions in the aorta and coronary arteries, which were not observed
in cholesterol-fed diabetic rats receiving concomitant supplementation
with 15% glucomannan, a soluble dietary fiber concentrate.
The present study was designed to examine the effects of the
dietary fiber supplementation on serum levels of glucose and
lipoproteins in cholesterol-fed diabetic rats. Feeding a diet
containing 1.5% cholesterol (wt/wt) and 0.37% cholic acid for
18 weeks to rats made diabetic by streptozotocin (35 mg/kg body
weight, iv) produced moderate hyperglycemia and moderate hypercholesterolemia,
the latter being characterized by high concentrations not only
of low density lipoproteins but also intermediate density lipoproteins
and very low density lipoproteins. These changes in serum lipoproteins
and hyperglycemia were substantially reduced by 18 weeks of
supplementation with glucomannan but high density lipoprotein
cholesterol and triglyceride levels did not change after feeding
a cholesterol-rich diet in the presence or absence of glucomannan
supplementation. These results suggest that amelioration in
hyperlipoproteinemia and hyperglycemia induced by the dietary
fiber supplementation may help retard or prevent the atheromatous
formation found in cholesterol-fed diabetic rats.
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