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| Metabolism 2000 Jan;49(1):67-72 |
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The
effect on serum lipids and oxidized low-density lipoprotein
of supplementing self-selected low-fat diets with soluble-fiber,
soy, and vegetable protein foods.
Jenkins DJ, Kendall CW, Vidgen E, Mehling CC, Parker T, Seyler
H, Faulkner D, Garsetti M, Griffin LC, Agarwal S, Rao AV, Cunnane
SC, Ryan MA, Connelly PW, Leiter LA, Vuksan V, Josse R.
Clinical Nutrition and Risk Factor Modification Center, Department
of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.
An increased intake of soluble fiber and soy protein may improve
the blood lipid profile. To assess any additional benefit on
serum lipids of providing soy protein and soluble-fiber foods
to hyperlipidemic subjects already consuming low-fat, low-cholesterol
therapeutic diets, 20 hyperlipidemic men and postmenopausal
women completed 8-week test and control dietary treatments in
a randomized crossover design as part of an ad libitum National
Cholesterol Education Program (NCEP) step 2 therapeutic diet
(<7% saturated fat and <200 mg/d cholesterol). During
the test phase, foods high in soy, other vegetable proteins,
and soluble fiber were provided. During the control phase, low-fat
dairy and low-soluble-fiber foods were provided. Fasting blood
lipid and apolipoprotein levels were measured at 4 and 8 weeks
of each phase. On the test diet, 12 +/- 2 g/d soy protein was
selected from the foods chosen. Direct comparison of test and
control treatments indicated an elevated high-density lipoprotein
(HDL) cholesterol concentration on the test diet (6.4% +/- 2.4%,
P = .013) and a significantly reduced total to HDL cholesterol
ratio (-5.9% +/- 2.3%, P = .020). The proportion of conjugated
dienes in the low-density lipoprotein (LDL) cholesterol fraction
was significantly reduced (8.5% +/- 3.3%, P = .020) as a marker
of oxidized LDL. A combination of acceptable amounts of soy,
vegetable protein, and soluble-fiber foods as part of a conventional
low-fat, low-cholesterol therapeutic diet is effective in further
reducing serum lipid risk factors for cardiovascular disease.
Publication Types:
- Clinical Trial
- Randomized Controlled Trial
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