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| Hypertension 2001 Oct;38(4):821-6 |
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Dietary
protein and soluble fiber reduce ambulatory blood pressure in
treated hypertensives.
Burke V, Hodgson JM, Beilin LJ, Giangiulioi N, Rogers P,
Puddey IB.
Department of Medicine, University of Western Australia, Royal
Perth Hospital and West Australian Heart Research Institute,
Perth, Australia. vburke@cyllene.uwa.edu.au
In population studies, higher blood pressure has been associated
with lower intake of protein and, possibly, lower fiber consumption.
In the present randomized controlled trial, we sought to determine
whether dietary protein and fiber had additive effects on blood
pressure reduction in hypertensives. Treated hypertensive patients
changed for 4 weeks (familiarization) to a diet low in protein
(12.5% energy) and fiber (15 g/d). Patients (n=41) were then
randomized to 1 of 4 groups in an 8-week factorial study of
parallel design in which they continued the low-protein, low-fiber
diet alone or had supplements of soy protein to increase protein
intake to 25% energy, of psyllium to provide an additional 12
g soluble fiber/d, or of both protein and fiber. The 24-hour
ambulatory blood pressure was compared from the end of familiarization
to the end of intervention. In the 36 subjects who provided
complete data, protein and fiber had significant additive effects
to lower 24-hour and awake systolic blood pressure. Relative
to control subjects, the net reduction in 24-hour systolic blood
pressure was 5.9 mm Hg with fiber and with protein. Findings
were independent of age, gender, and change in weight, alcohol
intake, or urinary sodium and potassium. Relative to reduced
fiber and protein intake, dietary protein and soluble fiber
supplements lower blood pressure additively in hypertensives.
These findings have important implications for the prevention
and management of hypertension, particularly in populations
in which high blood pressure is prevalent in association with
diets low in protein, fiber, or both.
Publication Types:
- Clinical Trial
- Randomized Controlled Trial
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